Key scientific discoveries 2010-2015

  • Sarcopenia and frailty are prevalent conditions in older men and women only recently recognised in clinical practice. 4, 5, 1
  • Poor growth in utero is linked to decreased muscle fibre number and lower muscle strength in older people.2
  • Unhealthy lifestyles (obesity, smoking, poor diet, physical inactivity) are strongly linked to poor physical function in later life. 3
  • Immune-endocrine biomarkers are powerful predictors of future frailty. 6, 7

Programme Leaders:

  • Professor Avan Aihie Sayer
  • Professor Siân Robinson,
  • Professor Catharine Gale
  • Professor Cyrus Cooper


  1. Patel HP, Syddall HE, Jameson K, Robinson S, Denison H, Roberts HC, Edwards M, Dennison E, Cooper C, Aihie SA. Prevalence of sarcopenia in community-dwelling older people in the UK using the European Working Group on Sarcopenia in Older People (EWGSOP) def3inition: findings from the Hertfordshire Cohort Study (HCS). Age Ageing 2013;42:378-384. [Info]
  2. Patel HP, Jameson KA, Syddall HE, Martin HJ, Stewart CE, Cooper C, et al. Developmental influences, muscle morphology, and sarcopenia in community-dwelling older men. J Gerontol A Biol Sci Med Sci. 2011/03/02 ed. 2012;67(1):82–7.[Info]
  3. Robinson SM, Jameson KA, Syddall HE, Dennison EM, Cooper C, Aihie SA. Clustering of lifestyle risk factors and poor physical function in older adults: the Hertfordshire cohort study. J Am Geriatr Soc 2013;61:1684-1691. [Info]
  4. Syddall H, Roberts HC, Evandrou M, Cooper C, Bergman H, Aihie SA. Prevalence and correlates of frailty among community-dwelling older men and women: findings from the Hertfordshire Cohort Study. Age Ageing 2010;39:197-203. [Info]
  5. Sayer AA. Sarcopenia. BMJ 2010;341:c4097. [Info]
  6. Baylis D, Bartlett DB, Syddall HE, Ntani G, Gale CR, Cooper C, Lord JM, Sayer AA. Immune-endocrine biomarkers as predictors of frailty and mortality: a 10-year longitudinal study in community-dwelling older people. Age (Dordr) 2013;35:963-971 [Info]
  7. Gale CR, Baylis D, Cooper C, Sayer AA. Inflammatory markers and incident frailty in men and women: the English Longitudinal Study of Ageing. Age (Dordr) 2013;35:2493-2501. [Info]