Our ongoing research aims to (a) understand better the mechanisms which underlie the development of osteoporosis, sarcopenia and osteoarthritis; and (b) develop intervention studies aimed at modifying later disease risk. Musculoskeletal disorders are associated with enormous health and social care costs.  Our research programme will permit the development of novel public health strategies to improve musculoskeletal health throughout the lifecourse and reduce osteoporotic fractures in future generations. The studies will optimise the use of cohort resources maintained at the centre, as well as incorporate research in other national and international resources such as UK Biobank and HealthABC. Mechanistic understanding will derive from biologic samples undergoing epigenetic, genomic, proteomic and metabolomic evaluation. These evaluations may allow the development of blood-based biomarkers to aid in enhanced stratification of risk for these disorders.