Key discoveries

  1. Confirmation that low maternal 25(OH)-vitamin D concentration during pregnancy is associated with reduced bone mass in the offspring Demonstration that maternal vitamin D supplementation during pregnancy improves offspring bone mass amongst winter births
  2. Characterisation of 25(OH)D across pregnancy and determinants of response to treatment
  3. Elucidation of aetiological factors underlying these epidemiological observations, such as the relationship between placental calcium transporters and offspring bone mass and epigenetic regulation of genes in umbilical cord
  4. Description of relationships between growth in utero, measured using gestational ultrasound scanning, and skeletal development in childhood
  • Professor Nicholas Harvey
  • Professor Elaine Dennison
  • Dr Kate Ward
  • Professor Cyrus Cooper