• Professor Nicholas C W Harvey
    • MA, MB, BChir, PhD, FRCP
    • Professor of Rheumatology and Clinical Epidemiology, Honorary Consultant Rheumatologist

    Nicholas Harvey is Professor of Rheumatology and Clinical Epidemiology at the MRC Lifecourse Epidemiology Unit, University of Southampton, having originally trained in medicine at the Universities of Oxford and Cambridge. He is Vice-Chair of the Royal Osteoporosis Society Osteoporosis and Bone Research Academy, and of the International Osteoporosis Foundation Committee of Scientific Advisors; he co-leads an MRC programme focused on the lifecourse epidemiology of bone and joint disease. His work thus incorporates a lifecourse approach to characterisation of the epidemiology and determinants of osteoporotic fracture from cradle to grave, elucidation of underlying mechanisms, and development of novel interventions. He has won many national/international prizes, such as the National Osteoporosis Society Kohn Award and International Osteoporosis Foundation Medal of Achievement. He is an investigator on >£50m grant funding and has published over 190 peer-reviewed papers (H-index 51). He serves the UK and global field as a member of the American Society for Bone and Mineral Research Professional Practice Committee, the UK National Osteoporosis Guideline Group Advisory Committee, Royal Osteoporosis Society (UK) Scientific Programme Committee, Bone Research Society (UK) Committee (2014-2018), UK Biobank Imaging Working Group (leading the DXA assessment of 100,000 individuals), Versus Arthritis Progress Review Committee and NIHR Research for Patient Benefit Regional Advisory Board (2016-2019). He serves as an associate editor for Archives of Public Health, and on the editorial boards of Bone and Osteoporosis International. He reviews regularly for JBMR, Bone, Osteoporosis International, Lancet, BMJ, NEJM, and for funding bodies such as UK Medical Research Council, BBSRC, EPSRC, Wellcome Trust, NIHR and INSERM.

    Background

    BA (Hons), Physiological Sciences, University of Oxford 1995
    MB BChir, University of Cambridge 1997
    MRCP, Medicine, Royal College of Physicians 2001
    MA, Physiological Sciences, University of Oxford 2003
    PhD, University of Southampton 2007
    CCT, Rheumatology, PMETB 2008
    FRCP, Medicine, Royal College of Physicians 2015

    01/08/15 to present Professor of Rheumatology and Clinical Epidemiology & Honorary Consultant Rheumatologist, Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, University Hospital NHS Trust, Southampton General Hospital, Tremona Road, SOUTHAMPTON SO16 6YD

    01/10/2014 – 31/07/2015 Associate Professor in Rheumatology and Clinical Epidemiology, Honorary Consultant Rheumatologist, University Hospital Southampton

    01/03/2011 – 30/09/2014 Senior Lecturer, University of Southampton; Honorary Consultant Rheumatologist, University Hospital Southampton

    01/08/2008 – 28/02/2011 Senior Clinical Research Fellow, University of Southampton; Honorary Consultant Rheumatologist, University Hospital Southampton

    26/02/07 – 01/08/2008 National Institute for Health Research Clinical Lecturer, University of Southampton

    10/06 – 10/07 Specialty Registrar Rheumatology, Christchurch Hospital

    10/03 – 10/06 Clinical Research Fellow, MRC ERC/UoS

    10/02 – 10/03 Specialty Registrar Rheumatology, Southampton General Hospital

    10/01 – 10/02 Specialty Registrar Rheumatology, Salisbury District Hospital

    Research

    Prof Harvey’s research achievements include:

    1. Comprehensive characterisation of the UK descriptive epidemiology of fractures, and related mortality and medication use (Curtis et al., Bone 2016; Moon et al., Bone 2016; van der Velde et al., Osteoporos Int 2016; Klop et al., Bone 2014; van der Velde et al., Bone 2017; Klop et al. Osteoporos Int 2017);
    2. Confirmation that low maternal 25(OH)-vitamin D concentration during pregnancy is associated with reduced bone mass in the offspring (Harvey et al., JCEM 2008; Javaid et al., Lancet 2006; Mahon et al., JBMR 2010);
    3. Demonstration that maternal vitamin D supplementation during pregnancy improves offspring bone mass amongst winter births (Cooper, Harvey et al., Lancet DE 2016);
    4. Characterisation of 25(OH)D across pregnancy and determinants of response to treatment (Moon et al., AJCN 2016; Moon et al., JCEM 2017);
    5. Description of relationships between growth in utero, measured using gestational ultrasound scanning, and skeletal development in childhood (Harvey et al., JBMR 2010, Harvey et al., PPE 2012; Harvey et al., Ped Res 2013);
    6. Elucidation of aetiological factors underlying these epidemiological observations, such as the relationship between placental calcium transporters and offspring bone mass (Martin et al., Bone 2007), and epigenetic regulation of genes in umbilical cord (Harvey et al., CTI 2012; Harvey et al., JBMR 2014; Curtis et al., JBMR 2017; Curtis et al., JBMR 2018);
    7. Demonstration that bariatric surgery does not appear to increase fracture risk, at least up to 5 years post-surgery (Lalmohamed et al., BMJ 2012).
    8. Demonstration of efficacy of teriparatide across baseline fracture risk distribution (Harvey et al., Osteoporos Int 2015a and b)
    9. Characterisation of falls as a risk factor for future falls and fractures (Harvey et al., Osteoporos Int 2015; Harvey et al., JBMR 2018)
    10. Elucidation of reassuring lack of association between calcium supplementation and cardiovascular events in the UK Biobank (Harvey et al., JBMR 2018)

    For further information regarding the MRC Lifecourse Epidemiology Unit (Director, Professor Cyrus Cooper), please go to: www.mrc.soton.ac.uk

    Responsibilities

    Grant reviewer for MRC, Arthritis Research UK, NOS, INSERM 2006-current
    Reviewer for Osteoporosis International, Bone, JBMR, JCEM,
    BMJ, Lancet, NEJM 2006-current
    External lecturer, Guys and St Thomas Hospital 2006-2008
    Bone Research Society Committee 2006-2010
    British Nutrition Foundation Task Force 2008-2013
    UK Biobank Imaging Working Group (DXA Lead) 2008-current
    National Osteoporosis Society Scientific Programme Committee 2008-current
    IOF Committee of Scientific Advisors 2011-current
    Editorial board member: Bone 2012-current
    Editorial board member: Osteoporosis International 2013-current
    Editorial board member: Archives of Public Health 2011-current
    Academic Editor: Frontiers in Bone Endocrinology 2010-current
    Academic Editor: PLOSone 2011-2018
    NIHR HTA Faculty 2010-current
    Bone Research Society Committe 2014-2018
    Arthritis Research UK Progress Review Committee 2015-current
    NIHR RfPB Regional Advisory Panel 2016-2019
    Vice-chair, IOF Committee of Scientific Advisors 2017-current
    Vice-chair, Osteoporosis and Bone Research Academy,
    Royal Osteoporosis Society 2019-current