Unique mother/offspring cohort in which women were recruited antenatally, with detailed phenotypic information on mother and offspring.
Randomised, placebo-controlled, double-blinded, factorial design trial of vitaimin D supplementation and healthy conversations intervention for optimisation of maternal diet, lifestyle, vitamin D status and offspring body composition and bone mass.
The Southampton Initiative for Health was a complex public health intervention developed to address inequalities in diet and lifestyle in disadvantaged women of childbearing age. It was designed in collaboration with Southampton City Council and Southampton Primary Care Trust to assess an empowerment approach in improving the health behaviour of women from disadvantaged backgrounds.
The Pune Maternal Nutrition Study (PMNS) was set up prospectively in 1994 in six villages near Pune city. The women, who were recruited before pregnancy, were undernourished and did heavy farming work even when pregnant. The children are now aged 18 years.
This cohort comprises 2,584 men and women, aged 42-45 years in 2014, who were born in Delhi in 1969-1972 and were measured (weight, height and head circumference) at birth and every six months until the age of 21 years.
This cohort comprises 2,572 men and women aged 42-45 years in 2014, who were born in Vellore and nearby rural villages in 1969-1972, and were measured (weight, height and head circumference) at birth, and in infancy (1-3 months), childhood (6-8 years) and adolescence (10-15 years). It was originally set up as a ‘twin’ study to the New Delhi Birth Cohort, to study pregnancy and infant outcomes, using common methodology.
This cohort was started prospectively in 1997-8 to assess the prevalence of gestational diabetes (GDM) and its impact on the children. The 550 urban and rural children are now aged 15-16 years.
This cohort comprises 1,069 urban adults recruited in 1993-2001, whose obstetric records from 1934-1954 (containing birthweight, length and head circumference) were preserved in the Holdsworth Memorial Hospital. The cohort was last studied in 2004 and is now aged 60-80 years; 652 cohort members are still alive and living in Mysore.
This cohort comprises 329 babies born to women with pre-eclampsia and 646 born to normotensive women in one Pune hospital during 2006-2010. Maternal plasma fatty acids, growth factors, 1-Carbon nutrients/metabolites, and oxidative stress markers were measured as well as cord blood fatty acids and brain-derived growth factor.
This cohort comprises 477 children born in the KEM Hospital, for whom birthweight was available from obstetric records. They had cardiometabolic risk factors measured at 8 years of age, and have recently been re-studied at 21 years. It is one of few cohorts that has blood measurements of cardiometabolic risk factors in childhood and young adult life. There are no plans to re-study this cohort in the next 5 years.
The Mumbai Maternal Nutrition Project, also known as Project “SARAS” (“excellent”) was a randomised controlled trial of a food-based supplement for women living in slums in the city of Mumbai. It was carried out in collaboration with Ramesh Potdar, Centre for the Study of Social Change, Mumbai. The children born to these women are also being followed up.
Adults aged 50-64 years with questionnaires about working life and health and linkage to anonymised health records.
The international CUPID cohort was incepted in the last quinquennium, coordinated at the MRC LEU. It includes 12,410 workers aged 20-59 years from 47 occupational groups in 18 countries across 5 continents.
During the 1980s, we established a series of longer-term occupational cohort studies to investigate known or suspected cancer hazards. By definition, such cohorts are difficult to incept and very long-term follow-up is required. As a result of careful maintenance, we have analysed data on workers exposed to: formaldehyde, phenoxy herbicides and styrene between 11 and 22 years in total, thereby publishing information vital to regulatory policy and practice not only in the UK but elsewhere
Compelling evidence that raised maternal insulin resistance in pregnancy is associated with an increased risk of obesity, together with impaired neuropsychological development and allergic and respiratory ill-health in children has led to the development of a supplement to reduce insulin resistance. A randomised controlled trial is being established to assess the effect of this supplement administered before and during pregnancy.
Building on the findings of the SWS and other studies that show the need to improve health behaviours before young people embark on their families, LifeLab is an educational programme based around a purpose-built laboratory that opened in September 2013 in Southampton General Hospital. A cluster-randomised trial of 32 schools is being conducted to assess the effectiveness.